Each version of Spider-Man should be immune to being a vampire for one important reason. Vampirism has quickly become essential to the Spider-Man mythos, specifically the Miles Morales version, as he recently became permanently a vampire. While it's certainly a unique power upgrade for Miles, it shouldn't be possible based on the past Spider-Man lore that Marvel established two decades ago.
2006 Blade #1 – written by Marc Guggenheim with art by Howard Chaykin – establishes a vital component to Peter Parker's Spider-Man that, in theory, should apply to all versions of Spider-Man going forward. The issue begins with Blade fighting a Spider-Man attacked by vampires, the latter losing the battle. While SHIELD is eliminating the latter, Blade says an important line.
Creatively, it could be an easy way to explain how Spider-Man returns to normal off-panel without devoting too much time to a mere special character. Yet, this line changes Spider-Man's physiology to vampires forever (or should have, if Marvel remembered that).
How Spider-Man's power works at the blood level
Spider's Blood, Explained
It is well documented that the radioactive spider that bit Peter Parker gave him the powers to become Spider-Man, but It's often forgotten how much this changed the entire formation of your DNA. Spider-Man's origin spider has its own origin, as it was mutated by gamma radiation. By biting Peter (and Cindy Moon, aka Silk), this radiation passed into Peter's physiology, changing it in the process. While the radiation he receives on Earth-616 doesn't make him as dangerously contagious as he would be in darker timelines, it still technically makes him radioactive.
If Spider-Man bleeds, his blood is not contagious. If your blood spills onto the ground in the middle of a fight, it won't affect the environment or harm a villain if it bleeds on him during a fight. The story suggests that after the contagion has reached his system, Spider-Man's blood is a contagion for him and him alone.. The same logic applies to other Spider-Men, including Miles, despite being bitten by a different spider in canon. It's worth noting that Peter also carries with him a mixture of Morbius' blood, which cured him of his six-armed disease.
How vampirism works in Spider-Man and other Marvel comics
How we understand
As much as vampirism has become entrenched in Spider-Man lore now, vampire lore itself is rich in the overall history of the Marvel Universe. While the since-reconfigured origin story of Marvel's vampires has framed them as the descendants of alien criminals, Marvel's current canon reaches back to prehistoric times via pop culture's original vampire, Varnae. Varnae was conceived by ancient Atlantean cultists who attempted to use magic to gain the power of the Elder God Chthon for themselves. The plan backfired, cursing one of its members, Varnae, with vampirism, the first of its kind.
Unlike Spider-Man's radioactive nature, vampirism is very contagious, hence how Varnae was able to spread his affliction from person to person by biting and taunting his victims. All subsequent vampires would follow suit, creating a population so large that vampires can be mentioned and created today without anyone knowing who Varnae is by name. Vampire physiology works the same way in Marvel and classic lorewhere once bitten, an aspiring vampire's enzymes transform his blood, transforming him into something other than a living human being.
How Spider-Man uses his blood to heal himself
Anti-Vampire Blood
Blade (2006) #1 opens immediately with The Daywalker facing off against a vampire Spider-Man. It's not explained how he became a vampire before the events of the comics, but seeing as Dracula appears moments after Blade incapacitates Spidey, it may be safe to assume that Vlad was Peter's father. After Blade knocks out Peter, stakes Dracula, and gets rid of a school full of vampire children, S.H.I.E.L.D.'s Howling Commandos arrive on the scene. As they carry Spidey on a stretcher, Blade advises them to tend to his wounds and let him sleep to rid himself of his vampirism.
When questioned further, Blade admits that he read in an Us Weekly article that Spider-Man has radioactive blood, telling him that the blood will kill the enzymes that turned Peter into a vampire.. Basically, it means Spider-Man can heal himself without lifting a finger. It's similar to the fairly recent revelation that Black Panther can cure his vampirism through the Heart-Shaped Herb in his system. Just as the herb works its magic slowly over time to rid any vampire viruses, so does Spider-Man's blood.
What does this mean for Spider-Man?
And Miles?
During last summer's "Blood Hunt" story arc, Blade is possessed by Varnae, and during his possession, he bites the Miles Morales version of Spider-Man. Even though Varnae was defeated and Blade's body once again belonged to him, Miles is still a vampire and until further notice, he may forever be a vampire with no cure in sight. Well, if Marvel remembered that Miles, like Peter, has self-healing radioactive blood, perhaps Miles would already be cured, but unfortunately, no one at Marvel seems to remember an 18-year-old Blade comic.
Miles' affliction is a little strange for any reader who remembers that 18-year-old Spider-Man reveal, but at least it's never too late if Marvel remembers a nearly two-decade-old story. . Or, perhaps, there's a chance Marvel never forgot. Maybe Marvel just hopes readers themselves have forgotten in hopes of surprising them when they least expect it.. After all, Peter Parker's vampiric affliction was said to fade slowly, but still, eventually. One would assume that if the radioactive blood worked the same way, Miles would have been cured by now.
However, since Miles is originally from Earth-1610, the spider that bit him could function differently than the one that bit Peter on Earth-616. Earth-1610 Ultimate Spider-Man establishes that Peter's Spider-Man is immune to becoming a vampire, and by proxy, Miles should too. Marvel could reveal that Miles is just getting a delayed response to his cure, giving Marvel a way out if they decide they want to undo Miles' vampirism. Alternatively, having Spider-Man Characters immune to vampirism add new layers to their lore and redefine who they are as horror characters whenever they battle creatures of the night.